Amplified Chiral Transformation through Helical Assembly

Authors

  • Kunihiko Toyofuku,

    1. Department of Chemistry and Biotechnology, School of Engineering and Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7310
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  • Md. Akhtarul Alam Dr.,

    1. Department of Chemistry and Biotechnology, School of Engineering and Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7310
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  • Akihiko Tsuda Dr.,

    1. Department of Chemistry and Biotechnology, School of Engineering and Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7310
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  • Norifumi Fujita Dr.,

    1. Department of Chemistry and Biotechnology, School of Engineering and Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7310
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  • Shigeru Sakamoto Dr.,

    1. Laboratory of Analytical Chemistry, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Shido, Sanuki-city 769-2193, Japan
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    • Responsible for cold-spray-ionization mass spectrometry.

  • Kentaro Yamaguchi Prof. Dr.,

    1. Laboratory of Analytical Chemistry, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Shido, Sanuki-city 769-2193, Japan
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    • Responsible for cold-spray-ionization mass spectrometry.

  • Takuzo Aida Prof. Dr.

    1. Department of Chemistry and Biotechnology, School of Engineering and Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7310
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  • The present work was sponsored by a Grants in Aid for Scientific Research (No. 17350044) and Encouragement of Young Scientists (No. 18750113) from the Ministry of Education, Science, Sports, and Culture, Japan. M.A.A. thanks the JSPS Postdoctoral Fellowship for Foreign Researchers.

Abstract

original image

Die Mehrheit bestimmt: „Chirale Verstärkung“ gelingt in asymmetrischen Umwandlungen, wenn ein helicales supramolekulares Polymer, das sich vom Substrat (S) ableitet, dem „Mehrheitsprinzip“ bei der Festlegung seiner Händigkeit gehorcht. Dieses Konzept funktioniert einwandfrei bei der asymmetrischen Umsetzung eines D2-symmetrischen sattelförmigen Porphyrins mit Chiralitätsgedächtnis.

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