Intracellular Hydrogelation of Small Molecules Inhibits Bacterial Growth

Authors

  • Zhimou Yang Dr.,

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China, Fax: (+852) 2358-1594
    Search for more papers by this author
  • Gaolin Liang Dr.,

    1. Center of Cancer Research, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China
    Search for more papers by this author
  • Zufeng Guo,

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China, Fax: (+852) 2358-1594
    Search for more papers by this author
  • Zhihong Guo Prof.,

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China, Fax: (+852) 2358-1594
    2. Center of Cancer Research, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China
    Search for more papers by this author
  • Bing Xu Prof.

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China, Fax: (+852) 2358-1594
    2. Center of Cancer Research, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China
    Search for more papers by this author

  • This work was partially supported by the Research Grants Council of Hong Kong (HKU2/05C, 604905, 600504), and HKUST (EHIA). B.X. thanks Dr. P. L. Ho for his suggestions in revising the manuscript.

Abstract

original image

Insider: Bei der Bildung eines supramolekularen Hydrogels in einer Zelle entstehen Nanostrukturen (siehe Bild), die das Schicksal von Bakterien beeinflussen. Die enzymgesteuerte Selbstorganisation niedermolekularer Vorstufen könnte zur Regulierung zellulärer Prozesse, zum Verständnis der Zellfunktionen und zur Entwicklung neuer Therapeutika durch supramolekulare Chemie beitragen.

Ancillary