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Enantioselective Synthesis of Complementary Double-Helical Molecules that Catalyze Asymmetric Reactions

Authors

  • Takashi Hasegawa,

    1. Yashima Super-structured Helix Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), 101 Creation Core Nagoya, 2266-22 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-0003, Japan, Fax: (+81) 52-739-2084
    2. Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan, Fax: (+81) 52-789-3185
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  • Yoshio Furusho Dr.,

    1. Yashima Super-structured Helix Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), 101 Creation Core Nagoya, 2266-22 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-0003, Japan, Fax: (+81) 52-739-2084
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  • Hiroshi Katagiri Dr.,

    1. Yashima Super-structured Helix Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), 101 Creation Core Nagoya, 2266-22 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-0003, Japan, Fax: (+81) 52-739-2084
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  • Eiji Yashima Prof.

    1. Yashima Super-structured Helix Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), 101 Creation Core Nagoya, 2266-22 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-0003, Japan, Fax: (+81) 52-739-2084
    2. Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan, Fax: (+81) 52-789-3185
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  • We thank Bruker AXS K.K. for providing generous access to the Bruker Smart Apex II CCD-based X-ray diffractometer. We also acknowledge Dr. Hiroshi Ito (JST) for his help with the X-ray single-crystal analysis.

Abstract

original image

Verdrillt: Optisch aktive Doppelhelices wurden synthetisiert, indem an einem der beiden komplementären Metallostränge durch einen chiralen Phosphanliganden eine Vorzugsverdrillung eingebracht wurde. Ein Austausch der chiralen Liganden gegen einen achiralen zweizähnigen Liganden führt zu einer Verbrückung der beiden Stränge. Diese Doppelhelices können die asymmetrische Cyclopropanierung effizient katalysieren.

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