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A Bright and Specific Fluorescent Sensor for Mercury in Water, Cells, and Tissue

Authors


  • This work was supported by the University of California, Berkeley, the National Science Foundation (CAREER CHE-0548245), and the Dreyfus, Beckman, Packard, and Sloan Foundations. E.W.M. was supported by a Chemical Biology Interface Training Grant from the NIH (T32 GM066698) and a Stauffer fellowship. We thank David Crane and Martice Vasquez (California Dept. of Fish and Game) and Richard Bauer (US EPA) for providing fish samples, and James Sanborn (California Office of Environmental Health Hazard Assessment) for helpful discussion.

Abstract

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Eine brillante Idee: Die eingeschränkte Rotation zwischen den Rezeptor- und Reporter-Einheiten des fluoreszierenden Chemosensors Mercury Green 1 (MG1) führt zu einer bemerkenswert hohen Quantenausbeute seiner Hg2+-gebundenen Form in Wasser (Φ=0.72). MG1 reagiert spezifisch auf Quecksilbermengen im ppm- bis ppb-Bereich und kann den Gehalt von Hg2+-Ionen in lebenden Zellen und in Speisefisch anzeigen.

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