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A Palladium-Catalyzed Regiospecific Synthesis of N-Aryl Benzimidazoles

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  • We thank the National Institutes of Health (GM 58160) and the National Cancer Institute (Cancer Training Grant CA09112) for support of this work. N.Z. acknowledges the National Institutes of Health for a postdoctoral fellowship (F32-GM074407). We are grateful to Merck, Amgen, and Boehringer Ingelheim for unrestricted support. The Varian 300 and 500 MHz instruments used in this study were purchased with funding from the National Science Foundation (CHE 9808061 and DBI 9729592). We thank Dr. Takashi Ikawa for developing a protocol for the conversion of 24 into 25.

Abstract

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Äußerst tolerant: Mit einem Katalysatorsystem aus [Pd2(dba)3] und XPhos oder RuPhos gelingt die effiziente, regioselektive Synthese von N-Arylbenzimidazolen ausgehend von ortho-Halogenaniliden (siehe Schema) in Gegenwart vielfältiger funktioneller Gruppen. dba=trans,trans-Dibenzylidenaceton.

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