Rational Design of a Fluorescence-Turn-On Sensor Array for Phosphates in Blood Serum

Authors

  • Grigory V. Zyryanov,

    1. Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA, Fax: (+1) 419-372-9809
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  • Manuel A. Palacios,

    1. Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA, Fax: (+1) 419-372-9809
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  • Pavel Anzenbacher Jr. Prof. Dr.

    1. Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA, Fax: (+1) 419-372-9809
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  • P.A. acknowledges support from the Alfred P. Sloan Foundation, BGSU (Technology Innovations Enhancement grant), and the NSF (SENSOR no. 0330267). M.A.P. acknowledges support from the McMaster Endowment. We would like to thank Prof. Franz P. Schmidtchen for helpful discussions during the preparation of this manuscript.

Abstract

original image

Mehr Licht: Um eine Größenordnung nimmt die Fluoreszenz einfacher Tripod-Sensoren in Gegenwart von Phosphatanionen zu. Die Röntgenstrukturanalyse eines der Komplexe (siehe Bild) belegt das Binden dreier Phosphatanionen, die dem anionischen Teil von ATP stark ähneln, durch den Sensor. Die Sensoren wurden für kreuzreaktive Arrays genutzt, die Anionen im menschlichen Serum nachweisen können.

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