Zuschrift

Total Synthesis of (+)-Fawcettimine†

  1. Xin Linghu Dr.,
  2. Joshua J. Kennedy-Smith Dr.,
  3. F. Dean Toste Prof.

Article first published online: 29 AUG 2007

DOI: 10.1002/ange.200702695

Issue

Angewandte Chemie

Angewandte Chemie

Volume 119, Issue 40, pages 7815–7817, October 8, 2007

Additional Information

How to Cite

Linghu, X., Kennedy-Smith, Joshua J. and Toste, F. Dean. (2007), Total Synthesis of (+)-Fawcettimine. Angew. Chem., 119: 7815–7817. doi: 10.1002/ange.200702695

Author Information

  1. Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720-1460, USA, Fax: (+1) 510-643-9480

  1. †

    We gratefully acknowledge the University of California, Berkeley, NIHGMS (R01 GM073932-01), Merck Research Laboratories, Bristol-Myers Squibb, Amgen Inc., DuPont, GlaxoSmithKline, Eli Lilly & Co., Pfizer, AstraZeneca, and Roche for financial support.

Publication History

  1. Issue published online: 28 SEP 2007
  2. Article first published online: 29 AUG 2007
  3. Manuscript Received: 19 JUN 2007

Funded by

  • University of California, Berkeley
  • NIHGMS. Grant Number: R01 GM073932-01
  • Merck Research Laboratories
  • Bristol-Myers Squibb
  • Amgen Inc.
  • DuPont
  • GlaxoSmithKline
  • Eli Lilly & Co.
  • Pfizer
  • AstraZeneca
  • Roche

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Keywords:

  • (+)-Fawcettimin;
  • Alkaloide;
  • Cyclisierungen;
  • Gold;
  • Totalsynthesen
Thumbnail image of graphical abstract

Eine effektive Kombination: Die erste asymmetrische Totalsynthese von Fawcettimin (1) beweist, dass die Kombination aus organokatalytischer Anellierung und Gold(I)-katalysierter Cyclisierung eine effektive Synthese komplexer Verbindungen ermöglicht. Die absolute Konfiguration von 1 wurde anhand einer Röntgenstrukturanalyse des Hydrobromids ermittelt.

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