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A Chiral Pool Based Synthesis of Platensimycin

Authors

  • K. C. Nicolaou Prof. Dr.,

    1. Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, no. 03-08, Singapore 138667, Singapore, Fax: (+1) 858-784-2469
    2. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    3. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
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  • Doron Pappo Dr.,

    1. Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, no. 03-08, Singapore 138667, Singapore, Fax: (+1) 858-784-2469
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  • Kit Y. Tsang Dr.,

    1. Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, no. 03-08, Singapore 138667, Singapore, Fax: (+1) 858-784-2469
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  • Romelo Gibe Dr.,

    1. Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, no. 03-08, Singapore 138667, Singapore, Fax: (+1) 858-784-2469
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  • David Y.-K. Chen Dr.

    1. Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, no. 03-08, Singapore 138667, Singapore, Fax: (+1) 858-784-2469
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  • We thank Doris Tan (ICES) for high-resolution mass-spectrometric (HRMS) assistance. Financial support for this work was provided by A*STAR, Singapore.

Abstract

original image

Ein direkter Weg führt zu dem Tetracyclus 2, einer späten Zwischenstufe in der Synthese des Breitbandantibiotikums (−)-Platensimycin (1). Zu diesem Zweck wird (R)-(−)-Carvon, eine billige Ausgangsverbindung aus dem chiralen Pool, einer Reihe von Cyclisierungen unterzogen.

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