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Palladium-Catalyzed Intermolecular Ene–Yne Coupling: Development of an Atom-Efficient Mizoroki–Heck-Type Reaction

Authors

  • Anders T. Lindhardt (neé Hansen) Dr.,

    1. The Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and Interdisciplinary Nanoscience Center University of Aarhus, Langelandsgade 140, 8000 Aarhus, Denmark, Fax: (+45) 8619-6199
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  • Mette Louise H. Mantel,

    1. The Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and Interdisciplinary Nanoscience Center University of Aarhus, Langelandsgade 140, 8000 Aarhus, Denmark, Fax: (+45) 8619-6199
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  • Troels Skrydstrup Prof. Dr.

    1. The Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and Interdisciplinary Nanoscience Center University of Aarhus, Langelandsgade 140, 8000 Aarhus, Denmark, Fax: (+45) 8619-6199
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  • We thank the Danish National Research Foundation, the Lundbeck Foundation, the Carlsberg Foundation, the OChem and INano Graduate Schools, and the University of Aarhus for generous financial support of this research. We thank Dr. Jacob Overgaard for X-ray crystallographic analysis, and we are grateful for a donation of ligands and catalysts from Degussa and Solvias. We thank Karin Dooleweerdt for synthesizing the ynamide.

Abstract

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Ohne Umschweife: Eine katalytische Palladiumhydridspezies eröffnet einen Zugang zu hoch substituierten 1,3-Dienen. Die direkte Kupplung von Alkinen mit Alkenen bei dieser basenfreien Mizoroki-Heck-Reaktion verläuft strikt atomökonomisch und ausschließlich über Palladium(II)-Komplexe (siehe Schema; R = Amid, Borat, C(OH)Me2, OAlkyl).

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