This work was partially supported by a Grant-in-Aid for Specially Promoted Research from MEXT, and a Grant-in-Aid for Encouragements for Young Scientists (B) (Y.S.), from JSPS, and Mitsubishi Chemical Corporation Fund (S.M.), and Toray Co Ltd.
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Zuschrift
A Heterobimetallic Pd/La/Schiff Base Complex for anti-Selective Catalytic Asymmetric Nitroaldol Reactions and Applications to Short Syntheses of β-Adrenoceptor Agonists†
Article first published online: 17 MAR 2008
DOI: 10.1002/ange.200705617
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Handa, S., Nagawa, K., Sohtome, Y., Matsunaga, S. and Shibasaki, M. (2008), A Heterobimetallic Pd/La/Schiff Base Complex for anti-Selective Catalytic Asymmetric Nitroaldol Reactions and Applications to Short Syntheses of β-Adrenoceptor Agonists. Angew. Chem., 120: 3274–3277. doi: 10.1002/ange.200705617
- †
Publication History
- Issue published online: 8 APR 2008
- Article first published online: 17 MAR 2008
- Manuscript Revised: 4 FEB 2008
- Manuscript Received: 8 DEC 2007
Funded by
- MEXT
- Young Scientists (B)
- JSPS
- Mitsubishi Chemical Corporation Fund
- Toray Co Ltd
Keywords:
- Agonisten;
- Aminoalkohole;
- Asymmetrische Katalyse;
- Nitroaldolreaktionen
Passgenau für zwei Metalle: Die Kombination aus Pd und La in einem Schiff-Base-Liganden führt zu einer anti-selektiven katalytischen asymmetrischen Nitroaldolreaktion (siehe Schema). Mithilfe des Heterodimetallkatalysators gelingen kurze Synthesen von β-Adrenozeptor-Agonisten.