Innentitelbild: O-Glycoside Orientation Is an Essential Aspect of Base J Recognition by the Kinetoplastid DNA-Binding Protein JBP1 (Angew. Chem. 16/2007)

Authors

  • Rajesh K. Grover Dr.,

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-7835
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  • Stephanie J. K. Pond Dr.,

    1. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
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  • Qizhi Cui Dr.,

    1. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
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  • Prem Subramaniam Dr.,

    1. Department of Infectology, Scripps Research Institute—Florida, 5353 Parkside Drive RF-2, Jupiter, FL 33458, USA
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  • David A. Case Prof.,

    1. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
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  • David P. Millar Prof.,

    1. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
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  • Paul Wentworth Jr. Prof.

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-7835
    2. The Scripps-Oxford Laboratory, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
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Abstract

Die Proteinerkennung durch DNA ist für die Steuerung der Genomexpression in lebenden Zellen essenziell. Kinetoplastiden wie die im Hintergrund wiedergegebenen verfügen über das Protein JBP1, das an doppelsträngige DNA bindet, die die gezeigte glycosylierte Base (Nucleosid dJ) enthält. In ihrer Zuschrift auf S. 2897 ff. analysieren P. Wentworth, Jr. et al. die Bindung und stellen fest, dass JBP1 eine entscheidende Edge-on-Konformation des Pyranosylrings von Nucleosid dJ erkennt. Diese Befunde sind für die Entwicklung neuer biologischer Ziele für antiparasitär wirksame Stoffe wichtig.

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