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Organocatalytic Asymmetric Formal [3+2] Cycloaddition Reaction of Isocyanoesters to Nitroolefins Leading to Highly Optically Active Dihydropyrroles

Authors

  • Chang Guo,

    1. Hefei National Laboratory for Physical Sciences at the Microscale, Joint Laboratory of Green Synthetic Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China, Fax: (+86) 551-360-6266
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  • Meng-Xia Xue,

    1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences (CAS), Chengdu, 610041, China
    2. Graduate School of CAS, Beijing, China
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  • Ming-Kui Zhu,

    1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences (CAS), Chengdu, 610041, China
    2. Graduate School of CAS, Beijing, China
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  • Liu-Zhu Gong Prof.

    1. Hefei National Laboratory for Physical Sciences at the Microscale, Joint Laboratory of Green Synthetic Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China, Fax: (+86) 551-360-6266
    2. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences (CAS), Chengdu, 610041, China
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  • We are grateful for financial support from the NSFC (20732006 and 20325211) and the Chinese Academy of Sciences.

Abstract

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Genaue Vorgaben für den Ringschluss: Asymmetrische formale [3+2]-Cycloadditionen von α-substituierten Isocyanestern und Nitroolefinen werden durch Cinchona-Alkaloide katalysiert und liefern 2,3-Dihydropyrrole mit hohen Diastereo- und Enantioselektivitäten (siehe Schema).

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