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Total Synthesis of (+)-Neopeltolide by a Prins Macrocyclization


  • This work was supported by a grant from MarineBio21, Ministry of Maritime Affairs and Fisheries, Korea, and a grant from the Center for Bioactive Molecular Hybrids (Yonsei University and KOSEF). BK21 graduate fellowship grants to M.S.K. are gratefully acknowledged.


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Kleine Ringe, große Ringe: Ein entscheidender Schritt bei der Totalsynthese von (+)-Neopeltolid war die intramolekulare Prins-Makrocyclisierung einer Aldehyd-Homoallylalkohol-Zwischenstufe (siehe Schema).