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Chiral Phosphoric Acid Catalyzed Enantioselective Friedel–Crafts Alkylation of Indoles with Nitroalkenes: Cooperative Effect of 3 Å Molecular Sieves

Authors

  • Junji Itoh Dr.,

    1. Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan, Fax: (+81) 3-5992-1029
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  • Kohei Fuchibe Dr.,

    1. Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan, Fax: (+81) 3-5992-1029
    2. Present address: Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Japan
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  • Takahiko Akiyama Prof. Dr.

    1. Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan, Fax: (+81) 3-5992-1029
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  • This work was partially supported by a Grant-in Aid for Scientific Research on Priority Areas “Advanced Molecular Transformation of Carbon Resources” from the Ministry of Education, Science, Sports, Culture, and Technology (Japan). J.I. thanks the JSPS Research Fellowships for Young Scientists.

Abstract

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Pfiffige Katalysatoren: Die Alkylierung von Indolen mit Nitroalkenen in Gegenwart des Phosphorsäurederivats 1 und eines 3-Å-Molekularsiebs liefert die Friedel-Crafts-Addukte mit ausgezeichneten Enantioselektivitäten (siehe Schema).

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