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Unprecedented Immunosuppressive Polyketides from Daldinia eschscholzii, a Mantis-Associated Fungus

Authors

  • Ying Lao Zhang,

    1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093 (China), Fax: (+86) 258-368-6559
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  • Hui Ming Ge Dr.,

    1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093 (China), Fax: (+86) 258-368-6559
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  • Wei Zhao,

    1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093 (China), Fax: (+86) 258-368-6559
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  • Hao Dong,

    1. School of Chemistry and Chemical Engineering, Institute of Theoretical and Computational Chemistry, Laboratory of Mesoscopic Chemistry, Nanjing University, Nanjing, 210093 (China)
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  • Qiang Xu Prof.,

    1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093 (China), Fax: (+86) 258-368-6559
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  • Shu Hua Li Prof.,

    1. School of Chemistry and Chemical Engineering, Institute of Theoretical and Computational Chemistry, Laboratory of Mesoscopic Chemistry, Nanjing University, Nanjing, 210093 (China)
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  • Jing Li,

    1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093 (China), Fax: (+86) 258-368-6559
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  • Jie Zhang,

    1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093 (China), Fax: (+86) 258-368-6559
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  • Yong Chun Song,

    1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093 (China), Fax: (+86) 258-368-6559
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  • Ren Xiang Tan Prof.

    1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093 (China), Fax: (+86) 258-368-6559
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  • This research was cofinanced by grants to R.X.T. from the NSFC (projects 20432030 and 30570010) and MOST (2007AA09Z400).

Abstract

original image

Heilkräftige Darmbewohner: Die Naturstoffe Dalesconol A (siehe Struktur rechts) und B wurden im Pilz Daldinia eschscholzii (Bild in der Mitte) gefunden, der aus dem Darm der Gottesanbeterin isoliert worden war. Ihre neuartigen Strukturen und biologischen Eigenschaften machen die Dalesconole zu vielversprechenden Leitverbindungen für die Entwicklung von Immunsuppressiva.

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