Tandem Catalytic Asymmetric Friedel–Crafts/Henry Reaction: Control of Three Contiguous Acyclic Stereocenters

Authors

Errata

This article is corrected by:

  1. Errata: Tandem Catalytic Asymmetric Friedel–Crafts/Henry Reaction: Control of Three Contiguous Acyclic Stereocenters Volume 122, Issue 50, 9748, Article first published online: 7 December 2010

  • This research was supported by the Industrial Technology Research Grant Program in 2006 from the New Energy and Industrial Technology Development Organization (NEDO) of Japan and by a Grant-in Aid for Scientific Research on Priority Areas (No. 19028007, “Chemistry of Concerto Catalysis”) from the Ministry of Education, Culture, Sports, Science and Technology (Japan). We thank Prof. Akira Yanagisawa at Chiba University for helpful discussions.

Abstract

original image

Dreierreihe: Hoch funktionalisierte Indolderivate mit drei benachbarten Stereozentren entstehen in der Titelreaktion aus einem Indol, einem Nitroalken und einem Aldehyd mit dem Imidazolin-Aminophenol 1 und CuOTf als Katalysator in Gegenwart von 1,1,1,3,3,3-Hexafluor-2-propanol (HFIP). Die Hauptisomere der Addukte wurden mit bis 99 % ee erhalten. Tf=Trifluormethansulfonyl, Ts=p-Toluolsulfonyl; R=H, Me; R′,R′′=Alkyl, Aryl.

Ancillary