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An Integrated Self-Assembled Nanofluidic System for Controlled Biological Chemistries

Authors

  • Pierre-Yves Bolinger Dr.,

    1. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland), Fax: (+41) 21-6936190
    2. Bio-Nanotechnology Laboratory, Department of Neuroscience and Pharmacology & Nano-Science Centre, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen (Denmark)
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  • Dimitrios Stamou Prof.,

    1. Bio-Nanotechnology Laboratory, Department of Neuroscience and Pharmacology & Nano-Science Centre, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen (Denmark)
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  • Horst Vogel Prof.

    1. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland), Fax: (+41) 21-6936190
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  • We thank N. Hatzakis, C. Danelon, and R. Trend for critically reading the manuscript and A. O. Dohn for the cover artwork. This work was performed at the EPFL (PhD thesis of P.Y.B.), funded by the TopNano21 programme and EPFL grants to H.V. We also acknowledge support from the Danish Research Councils to D.S. and postdoctoral fellowships from the Danish Research Councils and the Swiss National Foundation to P.Y.B.

Abstract

original image

Nacheinander laufen enzymatische Reaktionen beim Mischen von Attolitervolumina (freigesetzt aus nanometergroßen Lipidvesikeln) in einem geschlossenen Femtoliter-Reaktionsgefäß (einem großen unilamellaren Lipidvesikel) ab, wodurch die Zahl an Reaktantenmolekülen genau gesteuert und verfolgt werden kann. Die autonomen Nanoreaktoren benötigen keine Verbindungen nach draußen, was eine extreme Miniaturisierung ermöglicht.

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