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Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

Authors

  • Ji-Ho Park,

    1. Materials Science and Engineering Program, Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman, La Jolla, CA 92093 (USA)
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  • Geoffrey von Maltzahn,

    1. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
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  • Erkki Ruoslahti Prof.,

    1. Burnham Institute for Medical Research at UCSB, University of California, Santa Barbara, 1105 Life Sciences Technology Bldg, Santa Barbara, CA 93106 (USA)
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  • Sangeeta N. Bhatia Prof.,

    1. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
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  • Michael J. Sailor Prof.

    1. Materials Science and Engineering Program, Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman, La Jolla, CA 92093 (USA)
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  • This project was funded in part with federal funds from the National Cancer Institute of the National Institutes of Health (Contract No. R01A124427-02 and U01 HL 080718). M.J.S., E.R., and S.N.B. are members of the Moores UCSD Cancer Center and the UCSD NanoTUMOR Center, under the auspices of which this research was conducted and partially supported through an NIH Grant (U54 CA 119335). J.P. thanks the Korea Science and Engineering Foundation (KOSEF) for a Graduate Study Abroad Scholarship. We thank Dr. Edward Monosov for assistance with TEM analysis.

Abstract

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Multimodale Nanoassoziate aus magnetischen Nanopartikeln, Quantenpunkten und dem Tumortherapeutikum Doxorubicin in einer einzigen PEG-Phospholipid-Micelle wurden hergestellt (siehe Schema; PEG=Polyethylenglycol). Wenn diese Nanostrukturen das Zielpeptid F3 enthielten, ermöglichten sie simultan die gezielte Wirkstofffreigabe und das duale Abbilden von Tumorgewebe durch Nah-IR-Fluoreszenz und NMR-Spektroskopie.

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