Total Syntheses and Structural Revision of α- and β-Diversonolic Esters and Total Syntheses of Diversonol and Blennolide C

Authors

  • K. C. Nicolaou Prof. Dr.,

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-2469
    2. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
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  • Ang Li

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-2469
    2. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
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  • We thank Dr. R. K. Chadha, Dr. D. H. Huang, and Dr. G. Siuzdak for X-ray crystallographic, NMR spectroscopic, and mass spectrometric assistance, respectively. We also gratefully acknowledge Prof. S. Bräse and Prof. R. J. Capon for providing the spectra of synthetic diversonol and natural rugulotrosins, respectively, as well as Dr. D. J. Edmonds and Dr. A. F. Lenzen for helpful discussions. This work was supported by the National Institutes of Health, the Skaggs Institute for Chemical Biology, and a Bristol-Myers Squibb Graduate Fellowship (to A.L.).

Abstract

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Neue Zuordnung: Totalsynthesen der ursprünglich vorgeschlagenen Strukturen der natürlichen α- und β-Diversonolester (1 und 2) sowie Diversonol (3) führten zur Revision der Strukturen von 1 und 2 zu 4 bzw. 5.

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