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Unusual Chromophore and Cross-Links in Ranasmurfin: A Blue Protein from the Foam Nests of a Tropical Frog†

  1. Muse Oke Dr.2,‡,
  2. Rosalind Tan Yan Ching Dr.1,‡,
  3. Lester G. Carter Dr.2,
  4. Kenneth A. Johnson Dr.2,
  5. Huanting Liu Dr.2,
  6. Stephen A. McMahon Dr.2,
  7. Malcolm F. White Prof.2,
  8. Carlos Bloch Jr. Dr.4,
  9. Catherine H. Botting Dr.2,
  10. Martin A. Walsh Dr.5,
  11. Aishah A. Latiff Prof.6,
  12. Malcolm W. Kennedy Prof.3,
  13. Alan Cooper Prof.1,
  14. James H. Naismith Prof.2

Article first published online: 9 SEP 2008

DOI: 10.1002/ange.200802901

Issue

Angewandte Chemie

Angewandte Chemie

Volume 120, Issue 41, pages 7971–7974, September 29, 2008

Additional Information

How to Cite

Oke, M., Ching, R., Carter, L., Johnson, K., Liu, H., McMahon, S., White, M., Bloch, C., Botting, C., Walsh, M., Latiff, A., Kennedy, M., Cooper, A. and Naismith, J. (2008), Unusual Chromophore and Cross-Links in Ranasmurfin: A Blue Protein from the Foam Nests of a Tropical Frog. Angewandte Chemie, 120: 7971–7974. doi: 10.1002/ange.200802901

Author Information

  1. 1

    WestChem Department of Chemistry, University of Glasgow, Glasgow G12 8QQ (UK), Fax: (+44) 141-330-2910

  2. 2

    Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229

  3. 3

    Division of Environmental and Evolutionary Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ (UK)

  4. 4

    Embrapa Recursos Genéticos e Biotecnologia, Parque Estação Biológica, Asa Norte–Brasilia, 70910-900 (Brazil)

  5. 5

    Medical Research Council France, European Synchrotron Radiation Facility, F-38043, Grenoble CEDEX (France)

  6. 6

    Doping Control Centre Penang, Universiti Sains Malaysia, 11800 Minden, Penang (Malaysia)

  1. ‡

    These authors contributed equally to this work.

  1. †

    We thank the BBSRC, the Wellcome Trust, and the Scottish Higher Education Funding Council (SHEFC) for financial support and Dr. Neeta Sinnappah, Jeet Sukamaran, Norsham Yaakob, Aw Ai Fong, Lim Ming Sang, and Lim Tau Chin for help with fieldwork and sample collection.

Publication History

  1. Issue published online: 24 SEP 2008
  2. Article first published online: 9 SEP 2008
  3. Manuscript Received: 18 JUN 2008

Funded by

  • BBSRC
  • Wellcome Trust
  • Scottish Higher Education Funding Council (SHEFC)

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Keywords:

  • Chromophore;
  • Cofaktoren;
  • Proteinmodifikationen;
  • Proteinstrukturen;
  • Schäume

Graphical Abstract

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Ungewöhnliche Verknüpfung: Die 1.16-Å-Kristallstruktur von Ranasmurfin, einem blauen Protein, das aus den Schaumnestern des malaysischen Baumfrosches Polypedates leucomystax extrahiert wurde, lässt ungewöhnliche posttranslationale chemische Modifikationen erkennen. Der Chromophor enthält ein neuartiges, Zn-koordiniertes Verknüpfungsmotiv zwischen den Untereinheiten, das aus vier Resten (Lys-Tyr-Tyr-Lys) aufgebaut ist.

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