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Enantioselective Synthesis of All-Carbon Quaternary Stereogenic Centers by Catalytic Asymmetric Conjugate Additions of Alkyl and Aryl Aluminum Reagents to Five-, Six-, and Seven-Membered-Ring β-Substituted Cyclic Enones

Authors


  • The NIH (GM-47480) and the NSF (CHE-0715138) provided financial support. T.L.M. is grateful for LaMattina and Novartis graduate fellowships; M.K.B. was the recipient of a Bristol-Myers Squibb graduate fellowship. Mass spectrometry facilities at Boston College are supported by the NSF (CHE-0619576).

Abstract

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Effiziente katalytische Verfahren für asymmetrische konjugierte Additionen von Alkyl- und Arylaluminiumreagentien an nichtaktivierte β-substituierte Cyclopentenone (siehe Schema) werden durch Kupferkomplexe chiraler zweizähniger N-heterocyclischer Carbene vermittelt (z. B. aus 1) und führen zu quartären Kohlenstoffstereozentren.

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