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Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis†

  1. Víctor M. Hernández-Rocamora1,
  2. Beatriz Maestro Dr.1,
  3. Bas de Waal2,
  4. María Morales3,4,
  5. Pedro García Dr.3,4,
  6. E. W. Meijer Prof.2,
  7. Maarten Merkx Dr.2,
  8. Jesús M. Sanz Dr.1

Article first published online: 29 DEC 2008

DOI: 10.1002/ange.200803664

Issue

Angewandte Chemie

Angewandte Chemie

Volume 121, Issue 5, pages 966–969, January 19, 2009

Additional Information

How to Cite

Hernández-Rocamora, V., Maestro, B., de Waal, B., Morales, M., García, P., Meijer, E., Merkx, M. and Sanz, J. (2009), Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis. Angewandte Chemie, 121: 966–969. doi: 10.1002/ange.200803664

Author Information

  1. 1

    Instituto de Biología Molecular y Celular, Universidad Miguel Hernandez, Avda. de la Universidad s/n, 03202 Elche (Spain), Fax: (+34) 966-588-758 http://ibmc.umh.es/jmsanz/jmsanz.htm

  2. 2

    Laboratory for Chemical Biology, Eindhoven University of Technology, 5600MB, Eindhoven (The Netherlands), Fax: (+31) 40-245-1036

  3. 3

    Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas, CSIC

  4. 4

    CIBER de Enfermedades Respiratorias (CibeRes), Ramiro de Maeztu, 9, 28040 Madrid (Spain)

  1. †

    We would like to thank Xianwen Lou for GPC analysis and Biomedal S.L. for supplying the pALEX2-Ca-GFP plasmid to produce C-Lyt-GFP. This work was supported by a VIDI grant from the Netherlands Organisation for Scientific Research (grant 700.56.428), the Escuela Valenciana de Estudios para la Salud (Generalidad Valenciana, Spain, Grant 95/2005) and the Fundación Salvat Inquifarma (Spain). Ciber de Enfermedades Respiratorias (CibeRes) is an initiative of Spanish Instituto de Salud Carlos III. Additional funding was provided by the COMBACT program (S-BIO-0260/2006) of the Comunidad de Madrid. V.M.H.-R. was supported by a PhD fellowship from Spanish Ministry of Education.

Publication History

  1. Issue published online: 13 JAN 2009
  2. Article first published online: 29 DEC 2008
  3. Manuscript Revised: 14 OCT 2008
  4. Manuscript Received: 27 JUL 2008

Funded by

  • Netherlands Organisation for Scientific Research. Grant Number: 700.56.428
  • Escuela Valenciana de Estudios para la Salud. Grant Number: 95/2005
  • Fundación Salvat Inquifarma. Grant Number: S-BIO-0260/2006
  • Comunidad de Madrid

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Keywords:

  • Antimikrobielle Wirkstoffe;
  • Dendrimere;
  • Inhibitoren;
  • Medizinische Chemie;
  • Mehrbindigkeit

Graphical Abstract

Thumbnail image of graphical abstract

Dendritische Zellwandmimetika: Cholin bindende Proteine aus Streptococcus pneumoniae erkennen unterschiedliche Cholin-Architekturen auf bakteriellen Zellwänden. Cholinfunktionalisierte Dendrimere hemmen diese lebenswichtigen Enzyme stark, und mit einer 103- bis 104-fach höheren Affinität als freies Cholin: So werden Autolyse und Zelltrennung in Bakterienkulturen durch Konzentrationen im niedrigen mikromolaren Bereich inhibiert (siehe Bild).

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