Get access

Asymmetric Palladium-Catalyzed Intramolecular α-Arylation of Aldehydes

Authors


  • Generous financial support from the National Institutes of Health (GM46059) is gratefully acknowledged. J.G.-F. thanks the Spanish M.E.C. for Postdoctoral Fellowship. We also thank Merck, Boehringer Ingelheim, and Amgen for unrestricted support, as well as Chemetall (Cs2CO3) and BASF (Pd(OAc)2). The Varian 300 MHz used in this work was purchased with funding from the National Institutes of Health (GM 1S10RR13886-01). We thank Dr. P. Bazinet (MIT) for obtaining the X-Ray structure of 2 g.

Abstract

original image

Schlaue Ligandenwahl: Die erste asymmetrische palladiumkatalysierte intramolekulare α-Arylierung von α-verzweigten Aldehyden (siehe Schema) zeichnet sich durch hohe Ausbeuten und Enantioselektivitäten aus und könnte zahlreiche Anwendungen in der Synthese finden.

Ancillary