Synthesis of (Z)-1-Aza-1,3-enynes by the Cross-Coupling of Terminal Alkynes with Isocyanides Catalyzed by Rare-Earth Metal Complexes

Authors

  • Wen-Xiong Zhang Prof. Dr.,

    1. Organometallic Chemistry Laboratory, RIKEN (Advanced Science Institute), Hirosawa 2-1, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-4624665
    2. Beijing National Laboratory for Molecular Sciences (BNLMS) and College of Chemistry, Peking University, Beijing 100871 (China)
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  • Masayoshi Nishiura Dr.,

    1. Organometallic Chemistry Laboratory, RIKEN (Advanced Science Institute), Hirosawa 2-1, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-4624665
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  • Zhaomin Hou Prof. Dr.

    1. Organometallic Chemistry Laboratory, RIKEN (Advanced Science Institute), Hirosawa 2-1, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-4624665
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  • This work was partly supported by a Grant-in-Aid for Scientific Research on Priority Areas (No. 18065020, “Chemistry of Concerto Catalysis”) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, a Grant-in-Aid for Scientific Research (A; No. 18205010) from Japan Society for the Promotion of Science, and the National Natural Science Foundation of China (Nos. 20702003, 20521202).

Abstract

original image

Seltene Reaktivität: Ein zweikerniges Katalysatorintermediat führt zur Z-selektiven Kreuzkupplung von terminalen Alkinen mit Isocyaniden und liefert ausschließlich und erstmalig die (Z)-1-Aza-1,3-enine als Produkte (siehe Schema).

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