Easy Copper-Catalyzed Synthesis of Primary Aromatic Amines by Couplings Aromatic Boronic Acids with Aqueous Ammonia at Room Temperature

Authors

  • Honghua Rao,

    1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (PR China), Fax: (+86) 10-6278-1695
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  • Hua Fu Prof. Dr.,

    1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (PR China), Fax: (+86) 10-6278-1695
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  • Yuyang Jiang Prof. Dr.,

    1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (PR China), Fax: (+86) 10-6278-1695
    2. Key Laboratory of Chemical Biology (Guangdong Province), Graduate School of Shenzhen, Tsinghua University (PR China)
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  • Yufen Zhao Prof. Dr.

    1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (PR China), Fax: (+86) 10-6278-1695
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  • Financial support was provided by the National Natural Science Foundation of China (grant nos. 20672065, 20732004), the Ministry of Science and Technology of China (grant nos. 2007AA02Z160, 2006DFA43030). Programs for New Century Excellent Talents in University (grant no. NCET-05-0062) and Changjiang Scholars and Innovative Research Team in University (PCSIRT) (grant no. IRT0404) in China, and the Key Subject Foundation from the Beijing Department of Education (grant no. XK100030514) are acknowledged.

Abstract

original image

Eine Reaktion ohne Extras: Aromatische Boronsäuren wurden unter Kupferkatalyse mit billigem wässrigem Ammoniak zu primären aromatischen Aminen gekuppelt. Diese einfache und hoch effiziente Umsetzung gelingt an Luft und bei Raumtemperatur, und – was besonders wichtig ist – sie benötigt weder Base noch Ligand oder ein Additiv (siehe Schema).

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