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The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling

Authors

  • Tommaso Cupido,

    1. Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174 (USA), Fax: (+1) 650-723-2253
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    • These authors contributed equally to this work.

  • Paul G. Rack,

    1. Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174 (USA), Fax: (+1) 650-723-2253
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    • These authors contributed equally to this work.

  • Ari J. Firestone,

    1. Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174 (USA), Fax: (+1) 650-723-2253
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  • Joel M. Hyman Dr.,

    1. Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174 (USA), Fax: (+1) 650-723-2253
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  • Kyuho Han,

    1. Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174 (USA), Fax: (+1) 650-723-2253
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  • Surajit Sinha Dr.,

    1. Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174 (USA), Fax: (+1) 650-723-2253
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  • Cory A. Ocasio Dr.,

    1. Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174 (USA), Fax: (+1) 650-723-2253
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  • James K. Chen Prof. Dr.

    1. Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174 (USA), Fax: (+1) 650-723-2253
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  • We thank Dr. G. Heffner, B. Moree, and Prof. Dr. A. F. Straight for technical assistance. This work was supported by the Stanford Interdisciplinary Translational Research Program, the Sidney Kimmel Foundation for Cancer Research, the Astellas USA Foundation, and the Brain Tumor Society/Rachel Molly Markoff Foundation.

Abstract

Doppelfunktion: Die Titelverbindung, ein bereits identifizierter wirksamer Hemmstoff des Hedgehog-Signalwegs, der embryonischen Zellen notwendige Informationen für die Entwicklung liefert, moduliert die Genexpression von Hedgehog-Targets, indem sie Mikrotubuli depolymerisiert. Auf diesem Weg wurde eine doppelte Steuerungsfunktion des Zytoskeletts nachgewiesen (siehe Bild).

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