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Molecular Photoacoustic Tomography with Colloidal Nanobeacons

Authors

  • Dipanjan Pan Dr.,

    1. C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108 (USA), Fax: (+1) 314-454-7490
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    • These authors contributed equally to this work.

  • Manojit Pramanik,

    1. Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130 (USA), Fax: (+1) 314-935-7448
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    • These authors contributed equally to this work.

  • Angana Senpan Dr.,

    1. C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108 (USA), Fax: (+1) 314-454-7490
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  • Xinmai Yang,

    1. Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130 (USA), Fax: (+1) 314-935-7448
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  • Kwang H. Song,

    1. Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130 (USA), Fax: (+1) 314-935-7448
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  • Mike J. Scott,

    1. C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108 (USA), Fax: (+1) 314-454-7490
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  • Huiying Zhang,

    1. C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108 (USA), Fax: (+1) 314-454-7490
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  • Patrick J. Gaffney Dr.,

    1. Department of Surgery, St Thomas's Hospital, London (UK)
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  • Samuel A. Wickline Prof.,

    1. C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108 (USA), Fax: (+1) 314-454-7490
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  • Lihong V. Wang Prof.,

    1. Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130 (USA), Fax: (+1) 314-935-7448
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  • Gregory M. Lanza Prof.

    1. C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108 (USA), Fax: (+1) 314-454-7490
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  • Financial support from the AHA under grant number 0835426N (D.P.) and from NIH under grant numbers NS059302, CA119342 (G.M.L.), HL073646 (S.A.W.), U54 CA136398, R01EB000712, R01NS046214, and EB008085 (L.V.W.) is greatly appreciated.

Abstract

Erkennung von Engpässen: Goldhaltige Kolloidpartikel wie die abgebildeten GNBs („gold nanobeacons“) eignen sich als exogene Kontrastmittel zur Erkennung von Fibrin, einem biochemischen Anzeiger der Thrombenbildung. Fibrinbindende GNBs ergaben eine zehnfache Signalverstärkung bei der photoakustischen Tomographie im Nah-IR-Bereich und könnten daher für diagnostische Bildgebungsverfahren interessant sein.

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