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Mass Spectrometry Assisted Lithography for the Patterning of Cell Adhesion Ligands on Self-Assembled Monolayers

Authors

  • Young-Kwan Kim,

    1. Department of Chemistry and School of Molecular Science (BK21), Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea), Fax: (+82) 42-350-2810
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  • Soo-Ryoon Ryoo,

    1. Department of Chemistry and School of Molecular Science (BK21), Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea), Fax: (+82) 42-350-2810
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  • Sul-Jin Kwack,

    1. Department of Chemistry and School of Molecular Science (BK21), Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea), Fax: (+82) 42-350-2810
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  • Dal-Hee Min Prof. Dr.

    1. Department of Chemistry and School of Molecular Science (BK21), Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea), Fax: (+82) 42-350-2810
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  • This work was supported by the Korea Science & Engineering Foundation (KOSEF) through a general research grant (no. R01-2008-000-20301-0) and by the nano R&D program (no. 2008-04457) funded by the Korean government. We would like to thank Prof. Dr. Hee Cheul Choi at POSTECH for gold substrates and Prof. Dr. Ryong Ryoo, Prof. Dr. Juhyoun Kwack, and Prof. Dr. Yoonkey Nam at KAIST for their help with obtaining cell images. We thank Prof. Dr. Woon-Seok Yeo at Konkuk University for helpful discussions.

Abstract

Radierung auf Gold: Eine einfache und flexible Methode für die Erzeugung von Mustern von Zelladhäsionsliganden wurde entwickelt. Das lokale „Wegradieren“ von Tri(ethylenglycol)-Gruppen aus einer selbstorganisierten Monoschicht mithilfe eines MALDI-TOF-MS-Stickstofflasers und das Auffüllen der freigelegten Goldoberfläche mit einem Carbonsäure-funktionalisierten Alkanthiol ermöglicht die aufeinanderfolgende Immobilisierung von Maleimid und eines Zelladhäsionspeptids, das Zellen erkennen kann (siehe Schema).

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