Innentitelbild: Highly Selective Metal Catalysts for Intermolecular Carbenoid Insertion into Primary C[BOND]H Bonds and Enantioselective C[BOND]C Bond Formation (Angew. Chem. 50/2008)

Authors

  • Hung-Yat Thu Dr.,

    1. Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road (Hong Kong), Fax: (+852) 2857-1586
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  • Glenna So-Ming Tong Dr.,

    1. Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road (Hong Kong), Fax: (+852) 2857-1586
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  • Jie-Sheng Huang Dr.,

    1. Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road (Hong Kong), Fax: (+852) 2857-1586
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  • Sharon Lai-Fung Chan Dr.,

    1. Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road (Hong Kong), Fax: (+852) 2857-1586
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  • Qing-Hai Deng,

    1. Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences, 354 Feng Lin Road, Shanghai 200032 (China)
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  • Chi-Ming Che Prof. Dr.

    1. Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road (Hong Kong), Fax: (+852) 2857-1586
    2. Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences, 354 Feng Lin Road, Shanghai 200032 (China)
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Abstract

original image

Als Analogon eines Mikroreaktors, der zwölf Eingänge hat, von denen jedoch nur einer so groß ist, dass sekundäre C-H-Bindungen reaktive Metall-Carben-Gruppen erreichen, beschreiben C.-M. Che et al. in ihrer Zuschrift auf S. 9893 ff. einen Rhodiumkatalysator mit einem Doppeltaschenporphyrin, das sekundären C-H-Bindungen eine große sterische Hinderung auferlegt. Dadurch reagieren die weniger reaktiven primären C-H-Bindungen von n-Alkanen mit einer ungefähren Primär/Sekundär-Selektivität von 11:1.

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