Titelbild: Organocatalytic Asymmetric Inverse-Electron-Demand Aza-Diels–Alder Reaction of N-Sulfonyl-1-aza-1,3-butadienes and Aldehydes (Angew. Chem. 51/2008)

Authors

  • Bo Han,

    1. Key Laboratory of Drug Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (China), Fax: (+86) 28 85502609
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  • Jun-Long Li,

    1. Key Laboratory of Drug Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (China), Fax: (+86) 28 85502609
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  • Chao Ma,

    1. Key Laboratory of Drug Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (China), Fax: (+86) 28 85502609
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  • Shan-Jun Zhang,

    1. Key Laboratory of Drug Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (China), Fax: (+86) 28 85502609
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  • Ying-Chun Chen Prof. Dr.

    1. Key Laboratory of Drug Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (China), Fax: (+86) 28 85502609
    2. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041 (China)
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Abstract

original image

Die Aza-Diels-Alder-Reaktion … mit inversem Elektronenbedarf von N-Sulfonyl-1-aza-1,3-butadienen, die im Titelbild gezeigt ist, wurde mit einem α,α-Diphenylprolinol-OTMS-Ether als Katalysator untersucht. In ihrer Zuschrift auf S. 10119 ff. demonstrieren Y.-C. Chen und Mitarbeiter, wie dieser einfache Prozess hoch enantiomerenangereicherte Hemiaminal-Intermediate liefert, die leicht in vielfältige chirale Piperidine überführt werden können.

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