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Bioinspired Colorimetric Detection of Calcium(II) Ions in Serum Using Calsequestrin-Functionalized Gold Nanoparticles

Authors

  • Sunghyun Kim,

    1. Cell Dynamics Research Center, Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Gwangju 500-712 (South Korea), Fax: (+82) 62-970-2504
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  • Jeong Won Park,

    1. Cell Dynamics Research Center, Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Gwangju 500-712 (South Korea), Fax: (+82) 62-970-2504
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  • Dongkyu Kim,

    1. Cell Dynamics Research Center, Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Gwangju 500-712 (South Korea), Fax: (+82) 62-970-2504
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  • Daejin Kim,

    1. Cell Dynamics Research Center, Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Gwangju 500-712 (South Korea), Fax: (+82) 62-970-2504
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  • In-Hyun Lee,

    1. Cell Dynamics Research Center, Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Gwangju 500-712 (South Korea), Fax: (+82) 62-970-2504
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  • Sangyong Jon Prof.

    1. Cell Dynamics Research Center, Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Gwangju 500-712 (South Korea), Fax: (+82) 62-970-2504
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  • This work was supported by a grant from Cell Dynamics Research Center, KOSEF (S.J., S.K., and D.K.; R11-2007-007-03002-0) and by a grant from the Plant Technology Advancement Program funded by the Korean Ministry of Construction and Transportation (S.J., S.K., J.P., and D.K.; B01-03). We thank Prof. Yong Yeong Jeong at Chonnam National University Medical School for kindly providing samples of human serum.

Abstract

Zuviel Calcium im Blut? Mit Calsequestrin (CSQ) funktionalisierte Goldnanopartikel durchlaufen eine Calcium-abhängige CSQ-Polymerisation, die mit einem Farbwechsel (siehe Bild) und einer Niederschlagsbildung einhergeht. Dieses Sensorsystem ist spezifisch für Ca2+-Ionen. Die Unterschiede zwischen normalen und krankheitsbedingten (hypercalcämischen) Ca2+-Ionenkonzentrationen im Serum lassen sich mit bloßem Auge wahrnehmen.

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