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Disterolphospholipids: Nonexchangeable Lipids and Their Application to Liposomal Drug Delivery

Authors

  • Zhaohua Huang Dr.,

    1. Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, CA 94143-0912 (USA), Fax: (+1) 415-476-0688
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  • Mahmoud Reza Jaafari Dr.,

    1. Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, CA 94143-0912 (USA), Fax: (+1) 415-476-0688
    2. Current address: School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad (Iran)
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  • Francis C. Szoka Jr. Prof.

    1. Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, CA 94143-0912 (USA), Fax: (+1) 415-476-0688
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  • This research was supported by NIH EB003008, GM61851, and CA119343. We thank Nichole Macaraeg for the animal study, and Katherine Jerger for the leakage study.

Abstract

Cholesterin an der Kette: Der Cholesterinaustausch ist einer der Hauptgründe für die Unbeständigkeit von Liposomen im Blut. Durch Bildung eines kovalent verbundenen Cholesterin-Glycerophosphocholin-Hybrids bleibt der stabilisierende Effekt des freien Cholesterins erhalten, sein Austritt aus der Doppelschicht wird aber verhindert. Disterophospholipide wie 1 sind somit wertvolle Komponenten für Liposomenformulierungen.

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