Get access

Direct anti-Selective Catalytic Asymmetric Mannich-Type Reactions of α-Ketoanilides for the Synthesis of γ-Amino Amides and Azetidine-2-amides

Authors


  • We thank Z. Chen and H. Mihara at the University of Tokyo for helpful advice on this project, and T. Nitabaru and H. Morimoto for X-ray crystallography. This research was supported by Grants-in-Aid for Scientific Research (S), Scientific Research on Priority Areas (No. 20037010, Chemistry of Concerto Catalysis) (S.M.), and Young Scientists (A) (S.M.) from the JSPS and MEXT.

Abstract

Mannich 'mal anders: Der Dinickelkomplex einer Biphenyldiamin-Schiff-Base katalysiert die anti-selektive Mannich-Reaktion von α-Ketoaniliden (siehe Schema), die als nützliche Synthesebausteine für Azetidin-2-amide und α-Hydroxy-γ-aminoamide fungieren. Dieser Ansatz ergänzt konventionelle Mannich-Reaktionen, die β-Aminocarbonylverbindungen ergeben. o-Ns=o-Nitrobenzolsulfonyl.

original image
Get access to the full text of this article

Ancillary