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Expedient Synthesis of (−)-Amphidinolide X


  • This work was supported by a grant from the Marine Biotechnology Program funded by the Ministry of Land, Transport and Maritime Affairs, Republic of Korea, and a grant from the Center for Bioactive Molecular Hybrids (Yonsei University and KOSEF). A BK21 graduate fellowship grant and a Seoul Science Fellowship grant to J.H.J. are gratefully acknowledged.


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Spezifische Cyclisierungen: Die Totalsynthese von (−)-Amphidinolid X gelang mithilfe der SmI2-vermittelten 5-exo-Cyclisierung eines Aldehydo-β-alkoxyvinylsulfoxids und einer Ringschlussmetathese als Schlüsselschritten (siehe Schema; Tol = Tolyl).

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