A Synthesis of an Ionomycin Calcium Complex

Authors

  • Zhanghua Gao Dr.,

    1. The School of Chemistry and The Institute of Process Research and Development, Leeds University, Leeds LS2 9 JT (UK), Fax: (+44) 113-343-6401
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  • Yingfa Li Dr.,

    1. The School of Chemistry and The Institute of Process Research and Development, Leeds University, Leeds LS2 9 JT (UK), Fax: (+44) 113-343-6401
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  • John P. Cooksey Dr.,

    1. The School of Chemistry and The Institute of Process Research and Development, Leeds University, Leeds LS2 9 JT (UK), Fax: (+44) 113-343-6401
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  • Thomas N. Snaddon Dr.,

    1. The School of Chemistry and The Institute of Process Research and Development, Leeds University, Leeds LS2 9 JT (UK), Fax: (+44) 113-343-6401
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  • Stefan Schunk Dr.,

    1. The School of Chemistry and The Institute of Process Research and Development, Leeds University, Leeds LS2 9 JT (UK), Fax: (+44) 113-343-6401
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  • Eddy M. E. Viseux Dr.,

    1. The School of Chemistry and The Institute of Process Research and Development, Leeds University, Leeds LS2 9 JT (UK), Fax: (+44) 113-343-6401
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  • Stephen M. McAteer Dr.,

    1. The School of Chemistry and The Institute of Process Research and Development, Leeds University, Leeds LS2 9 JT (UK), Fax: (+44) 113-343-6401
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  • Philip J. Kocienski Prof. Dr.

    1. The School of Chemistry and The Institute of Process Research and Development, Leeds University, Leeds LS2 9 JT (UK), Fax: (+44) 113-343-6401
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  • We thank Prof. Norbert Krause (University of Dortmund) for helpful advice as well as the Deutsche Forschungsgemeinschaft, the Engineering and Physical Sciences Research Council, and Pfizer Central Research (Sandwich) for financial support.

Abstract

Mit Kupfer, Gold und Rhodium zum Calciumkomplex von Ionomycin (siehe Struktur; O rot, Ca grün): Dafür wurde die effiziente Synthese eines Allens durch eine CuI-vermittelte anti-selektive SN2′-Reaktion mit einer hoch stereoselektiven AuIII-katalysierten Cycloisomerisierung eines α-Hydroxyallens und einer Rh-katalysierten Umlagerung eines α-Diazo-β-hydroxyketons kombiniert.

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