Spiro[4,4]-1,6-nonadiene-Based Phosphine–Oxazoline Ligands for Iridium-Catalyzed Enantioselective Hydrogenation of Ketimines

Authors

  • Zhaobin Han,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P.R. China), Fax: (+86) 21-6416-6128
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  • Zheng Wang Dr.,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P.R. China), Fax: (+86) 21-6416-6128
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  • Xumu Zhang Prof. Dr.,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P.R. China), Fax: (+86) 21-6416-6128
    2. Department of Chemistry and Chemical Biology, The State University of New Jersey, Piscataway (USA)
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  • Kuiling Ding Prof. Dr.

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P.R. China), Fax: (+86) 21-6416-6128
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  • Financial support from the National Natural Science Foundation of China (grant nos. 20532050, 20632060, and 20620140429), the Chinese Academy of Sciences, the Major Basic Research Development Program of China (grant no. 2006CB806106), the Science and Technology Commission of Shanghai Municipality, and Merck Research Laboratories is gratefully acknowledged.

Abstract

Von Iminen zu Aminen durch Katalyse mit IrI-Komplexen eines neuartigen P,N-Liganden (siehe Schema): Die Titelreaktion liefert die entsprechenden optisch aktiven Amine mit bis zu 98 % ee und ermöglichte die perfekt stereoselektive Synthese von Sertralin (1), einem wichtigen Antidepressivum.

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