The True Structures of the Vannusals, Part 1: Initial Forays into Suspected Structures and Intelligence Gathering

Authors

  • K. C. Nicolaou Prof. Dr.,

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA), Fax: (+1) 858-784-2469
    Search for more papers by this author
  • Hongjun Zhang Dr.,

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA), Fax: (+1) 858-784-2469
    Search for more papers by this author
  • Adrian Ortiz

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA), Fax: (+1) 858-784-2469
    Search for more papers by this author

  • We thank Prof. Graziano Guella for samples and NMR spectra of vannusals A and B, and for helpful discussions. We also thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectroscopic, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by the NSF (fellowship to A.O.), the Skaggs Institute for Research, and a grant from the National Institutes of Health (USA). We thank Prof. Y. Iwabuchi and Nissan Chemical Industries, Ltd. for generous gifts of AZADO and 1-Me-AZADO catalysts.

Abstract

original image

Zwei weitere vermutete Strukturen ausgeschlossen: Die Totalsynthesen der gezeigten Verbindungen schufen die Grundlage für die Aufklärung der wahren Struktur des marinen Naturstoffs Vannusal B und seines Verwandten, Vannusal A.

Ancillary