Get access

Copper-Catalyzed Cross-Couplings with Part-per-Million Catalyst Loadings


  • We are grateful to the Fonds der Chemischen Industrie, the Swedish Research Council, and AstraZeneca for financial support and we acknowledge the EU for financing a Short Term Scientific Mission within the COST D40 program of P.-F.L. We thank Prof. Dr. S. L. Buchwald for kindly sharing unpublished data and for alerting us to his findings of the cross-coupling activity of ppm amounts of Cu2O. We also thank Prof. Dr. R. Dronskowski and L. Stork (Institute for Inorganic Chemistry, RWTH Aachen University) for substrate analyses by atom absorption spectroscopy and Dr. E. Zuidema, I. Thomé, J. Bonnamour and A. Beyer for stimulating discussions and performing various control experiments.


original image

Homöopathische Dosen: 0.001 Mol-% eines Kupfersalzes können genügen, um Arylierungen zahlreicher Nucleophile mit Phenyliodid zu katalysieren. Die zwei wichtigsten Faktoren für den Reaktionsverlauf sind die Ligandenmenge und die Temperatur.

Get access to the full text of this article