Selective Aggregation of a Platinum–Gadolinium Complex Within a Tumor-Cell Nucleus


  • We are most grateful to Dr. A. Levina and Dr. P. Witting (The University of Sydney) for their valuable assistance with the ICP-MS analyses of tumor and endothelial cells, P. MacKay (The University of Sydney) for the preparation of cells for the XRF studies, and Dr. R. Clarke (The University of Sydney) for enlightening discussions. This research was supported by the Australian Synchrotron Research Program, which is funded by the Commonwealth of Australia under the Major National Research Facilities Program. The use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, under contract no. W-31-109-Eng-38. The research was also supported by Australian Research Council grants to L.M.R. (DP0986055) and H.H.H. (DP0984722 and DP0985807 (QEII Fellowship)).


original image

Per Anhalter in den Zellkern: Ein in DNA intercalierter Metallkomplex kann die selektive Ansammlung eines intakten Wirkstoffs in den Kernen von humanen Lungenkrebszellen (A549) ermöglichen. Mit einem Platinkomplex gelang es nun, auf diesem Weg Gadolinium in Zellkerne zu schleusen. Die Synchrotron-Röntgenfluoreszenz-Bildgebung diente zum Nachweis des Prozesses (siehe Bilder).