Direct Transformation of Methyl Arenes to Aryl Nitriles at Room Temperature

Authors

  • Wang Zhou,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191 (China), Fax: (+86) 10-8280-5297
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  • Liangren Zhang Dr.,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191 (China), Fax: (+86) 10-8280-5297
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  • Ning Jiao Dr.

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191 (China), Fax: (+86) 10-8280-5297
    2. State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032 (China)
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  • Financial support from Peking University, the National Science Foundation of China (nos. 20702002, 20872003), and the National Basic Research Program of China (973 Program; grant no. 2009CB825300) is greatly appreciated. We thank Chun Zhang for reproducing the results of entries 4 and 9 in Table 2.

Abstract

original image

Drei C-H-Bindungen werden bei der direkten Umwandlung von Methylarenen in Arylnitrile unter milden neutralen Bedingungen gespalten (siehe Schema). Dieses Verfahren liefert synthetisch und medizinisch wichtige Arylnitrile unter C-H-Funktionalisierung. PIDA=Phenyliodoniumdiacetat.

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