This work is supported by PRESTO (Japan) Science and Technology Agency (JST) and Exploratory Research 21655074 from MEXT. N.L. acknowledges a fellowship from the Chinese government. We would like to thank Dr. Paul Eggers for his critical reading of the manuscript.
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Zuschrift
Mechanistic Studies by Sum-Frequency Generation Spectroscopy: Hydrolysis of a Supported Phospholipid Bilayer by Phospholipase A2†
Article first published online: 4 MAR 2010
DOI: 10.1002/ange.200904950
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Tong, Y., Li, N., Liu, H., Ge, A., Osawa, M. and Ye, S. (2010), Mechanistic Studies by Sum-Frequency Generation Spectroscopy: Hydrolysis of a Supported Phospholipid Bilayer by Phospholipase A2. Angew. Chem., 122: 2369–2373. doi: 10.1002/ange.200904950
- †
Publication History
- Issue published online: 17 MAR 2010
- Article first published online: 4 MAR 2010
- Manuscript Revised: 17 DEC 2009
- Manuscript Received: 3 SEP 2009
Funded by
- PRESTO (Japan) Science and Technology Agency (JST). Grant Number: 21655074
- MEXT
Keywords:
- Hydrolyse;
- Lipiddoppelschichten;
- Phospholipase A2;
- Strukturaufklärung;
- Summenfrequenzspektroskopie
Die Strukturänderungen bei der durch das PLA2-Enzym katalysierten Hydrolyse einer DPPC-Doppelschicht und der Mechanismus dieser Reaktion wurden auf molekularer Ebene für jede Schicht (rot und schwarz) der trägerfixierten Lipiddoppelschicht mithilfe von Summenfrequenzspektroskopie untersucht (DPPC=Dipalmitoylphosphatidylcholin).