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Gold(I)-Catalyzed Enantioselective Synthesis of Pyrazolidines, Isoxazolidines, and Tetrahydrooxazines


  • We gratefully acknowledge NIHGMS (R01 GM073932-04S1), Bristol-Myers Squibb, and Novartis for funding. R.L.L. thanks Novartis and Eli Lilly and Z.J.W. thanks the Hertz Foundation for graduate fellowships. We thank Dr. Francesco Santoro for preliminary studies on the synthesis of silver biarylsulfonates. We are grateful Johnson Mathey for a generous donation of AuCl3 and to Takasago and Solvias for providing Segphos and MeOBiPhep ligands, respectively.


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Auf das Substrat abgestimmt: Chirale Liganden L* und chirale Anionen, wie in (S)-TriP Ag, wurden in Gold(I)-katalysierten enantioselektiven intramolekularen Additionen von Hydrazinen und Hydroxylaminen an Allene eingesetzt. Diese komplementären Ansätze ebnen den Weg zu den Titelverbindungen in chiraler Form. PNB=para-Nitrobenzoyl.

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