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Highly Stereoselective Synthesis of Monofluoroalkenes from α-Fluorosulfoximines and Nitrones

Authors

  • Wei Zhang,

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 (China), Fax: (+86) 21-6416-6128
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  • Weizhou Huang,

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 (China), Fax: (+86) 21-6416-6128
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  • Jinbo Hu Prof. Dr.

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 (China), Fax: (+86) 21-6416-6128
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  • We thank the National Natural Science Foundation of China (20772144, 20825209, 20832008) and the Chinese Academy of Sciences (Hundreds-Talent Program and Knowledge Innovation Program) for financial support.

Abstract

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Kupplung mit F: α-Fluorsulfoximine reagieren bereitwillig und hoch E/Z-selektiv mit einfachen Nitronen zu Monofluoralkenen (siehe Schema). Weil diese Produkte potenzielle Mimetika für Peptiduntereinheiten als Proteininhibitoren sind, erscheint das neuartige Fluorolefinierungsverfahren aussichtsreich für Anwendungen in der medizinischen Chemie.

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