Zuschrift

Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines†

  1. James M. Macdonald Dr.1,4,
  2. Chris A. Tarling Dr.1,
  3. Edward J. Taylor Dr.2,
  4. Rebecca J. Dennis Dr.2,
  5. David S. Myers3,
  6. Spencer Knapp Prof.3,
  7. Gideon J. Davies Prof.2,
  8. Stephen G. Withers Prof.1

Article first published online: 5 MAR 2010

DOI: 10.1002/ange.200906644

Issue

Angewandte Chemie

Angewandte Chemie

Volume 122, Issue 14, pages 2653–2656, March 29, 2010

Additional Information

How to Cite

Macdonald, J., Tarling, C., Taylor, E., Dennis, R., Myers, D., Knapp, S., Davies, G. and Withers, S. (2010), Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines. Angewandte Chemie, 122: 2653–2656. doi: 10.1002/ange.200906644

Author Information

  1. 1

    Department of Chemistry, University of British Columbia, Vancouver, V6T1Z3 (Canada), Fax: (+1) 604-822-8869

  2. 2

    Department of Chemistry, The University of York, Heslington, York, YO10 5YW (UK)

  3. 3

    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA)

  4. 4

    Current address: CSIRO Molecular and Health Technologies, Clayton, Vic 3169 (Australia)

  1. †

    We thank the Canadian Institutes for Health Research (CIHR) for funding to S.G.W. and the BBSRC for funding to G.J.D. E.J.T. is a Royal Society University Research Fellow, and G.J.D. is a Royal Society/Wolfson Research Merit Award recipient.

Publication History

  1. Issue published online: 23 MAR 2010
  2. Article first published online: 5 MAR 2010
  3. Manuscript Received: 25 NOV 2009

Funded by

  • Canadian Institutes for Health Research (CIHR)
  • BBSRC

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (389K)

Keywords:

  • Enzyminhibitoren;
  • Fungizide;
  • Insektizide;
  • Kohlenhydrate;
  • Thiazoline

Graphical Abstract

Thumbnail image of graphical abstract

Gut nachgemacht: Di- und Trisaccharidanaloga des Oxazolinintermediats der enzymatischen Hydrolyse von Chitin sind gute Chitinase-A-Inhibitoren. Wegen der hohen Affinität und enzymatischen Stabilität eines einfach zugänglichen Thioamidtrisaccharids (zwei Moleküle sind im aktiven Zentrum des Enzyms gezeigt) sowie der mechanismusbasierten Wirkungsweise ist dieses Analogon ein vielversprechender Kandidat für eine Breitband-Chitinase-Inhibierung.

View Full Article with Supporting Information (HTML) Get PDF (389K)