Get access
Advertisement

Chemical Proteomics Discloses Petrosapongiolide M, an Antiinflammatory Marine Sesterterpene, as a Proteasome Inhibitor

Authors

  • Luigi Margarucci,

    1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano (Italy), Fax: (+39) 089-969-602
    Search for more papers by this author
  • Maria Chiara Monti Dr.,

    1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano (Italy), Fax: (+39) 089-969-602
    Search for more papers by this author
  • Alessandra Tosco Dr.,

    1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano (Italy), Fax: (+39) 089-969-602
    Search for more papers by this author
  • Raffaele Riccio Prof.,

    1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano (Italy), Fax: (+39) 089-969-602
    Search for more papers by this author
  • Agostino Casapullo Prof.

    1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano (Italy), Fax: (+39) 089-969-602
    Search for more papers by this author

  • Financial support from the University of Salerno is gratefully acknowledged. We acknowledge the use of the instrumental facilities of the Centre of Competence in Diagnostics and Molecular Pharmaceutics supported by Regione Campania (Italy) through POR funds. Angela Anzovino, Maria Anna Euterpio, and Sandro Montefusco are also acknowledged for their contribution.

Abstract

original image

PM als Köder: Das marine γ-Hydroxybutenolid-Sesterterpenoid Petrosaspongiolid M (PM) wurde an einer Festphase immobilisiert, um selektiv seine makromolekularen Zielstrukturen in einem Makrophagen-Zelllysat anzulagern. Dabei erwies sich das Proteasom als wichtigster Bindungspartner.

Get access to the full text of this article

Ancillary