Titelbild: Polyketide-Chain Branching by an Enzymatic Michael Addition (Angew. Chem. 27/2009)

Authors

  • Björn Kusebauch,

    1. Leibniz Institute for Natural Product Research and Infection Biology, HKI, Department of Biomolecular Chemistry and Bio Pilot Plant, Beutenbergstrasse 11a, 07745 Jena (Germany), Fax: (+49) 3641-532-0804
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    • These authors contributed equally to this work.

  • Benjamin Busch,

    1. Leibniz Institute for Natural Product Research and Infection Biology, HKI, Department of Biomolecular Chemistry and Bio Pilot Plant, Beutenbergstrasse 11a, 07745 Jena (Germany), Fax: (+49) 3641-532-0804
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    • These authors contributed equally to this work.

  • Kirstin Scherlach Dr.,

    1. Leibniz Institute for Natural Product Research and Infection Biology, HKI, Department of Biomolecular Chemistry and Bio Pilot Plant, Beutenbergstrasse 11a, 07745 Jena (Germany), Fax: (+49) 3641-532-0804
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    • These authors contributed equally to this work.

  • Martin Roth Dr.,

    1. Leibniz Institute for Natural Product Research and Infection Biology, HKI, Department of Biomolecular Chemistry and Bio Pilot Plant, Beutenbergstrasse 11a, 07745 Jena (Germany), Fax: (+49) 3641-532-0804
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  • Christian Hertweck Prof. Dr.

    1. Leibniz Institute for Natural Product Research and Infection Biology, HKI, Department of Biomolecular Chemistry and Bio Pilot Plant, Beutenbergstrasse 11a, 07745 Jena (Germany), Fax: (+49) 3641-532-0804
    2. Friedrich Schiller University, Jena (Germany)
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Abstract

Der Pilz Rhizopus microsporus , der auf dem Titelbild unter dem Mikroskop betrachtet wird, beherbergt das endosymbiotische Bakterium Burkholderia rhizoxinica, den Produzenten des antimitotischen Polyketidmakrolids Rhizoxin (siehe Struktur). In ihrer Zuschrift auf S. 5101 ff. belegen C. Hertweck und Mitarbeiter, dass nur das Enzym Rhizoxin-Polyketidsynthase in der Lage ist, durch die Michael-Addition einer Malonyl-Einheit an ein Acryloyl-Intermediat eine β-Verzweigung einzuführen. Der entsprechende Molekülteil ist bildlich unter die Lupe genommen.

original image

Ancillary