Bimodal MR–PET Agent for Quantitative pH Imaging

Authors

  • Luca Frullano Dr.,

    1. A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Suite 2301, Charlestown, MA 02129 (USA), Fax: (+1) 617-726-7422
    Search for more papers by this author
  • Ciprian Catana Dr.,

    1. A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Suite 2301, Charlestown, MA 02129 (USA), Fax: (+1) 617-726-7422
    Search for more papers by this author
  • Thomas Benner Dr.,

    1. A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Suite 2301, Charlestown, MA 02129 (USA), Fax: (+1) 617-726-7422
    Search for more papers by this author
  • A. Dean Sherry Prof.,

    1. Department of Chemistry, University of Texas at Dallas and Advanced Imaging Research Center, Dallas (USA)
    Search for more papers by this author
  • Peter Caravan Prof.

    1. A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Suite 2301, Charlestown, MA 02129 (USA), Fax: (+1) 617-726-7422
    Search for more papers by this author

  • This research was supported in part by the National Institute of Biomedical Imaging and Bioengineering, R21EB009738. MR–PET=magnetic resonance–positron emission tomography.

Abstract

original image

Zwei Unbekannte: Die Relaxivität aktivierbarer Magnetresonanz(MR)-Kontrastmittel wird durch Faktoren wie pH-Wert oder Enzymaktivität beeinflusst, doch das MR-Signal hängt von der Relaxivität und der Kontrastmittelkonzentration ab. Simultane Positronenemissionstomographie (PET) und MR-Bildgebung (MRI) mit dem gezeigten bimodalen pH-empfindlichen MR-PET-Agens ermöglicht es, die Konzentration und T1, und somit den pH-Wert, direkt zu bestimmen.

Ancillary