Glucose Activation by Transient Cr2+ Dimers

Authors

  • Evgeny A. Pidko Dr.,

    1. Schuit Institute of Catalysis, Eindhoven University of Technology, P.O. Box 513, NL-5600 MB, Eindhoven (The Netherlands), Fax: (+31) 40-245-5054
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  • Volkan Degirmenci Dr.,

    1. Schuit Institute of Catalysis, Eindhoven University of Technology, P.O. Box 513, NL-5600 MB, Eindhoven (The Netherlands), Fax: (+31) 40-245-5054
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  • Rutger A. van Santen Prof. Dr.,

    1. Schuit Institute of Catalysis, Eindhoven University of Technology, P.O. Box 513, NL-5600 MB, Eindhoven (The Netherlands), Fax: (+31) 40-245-5054
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  • Emiel J. M. Hensen Prof. Dr.

    1. Schuit Institute of Catalysis, Eindhoven University of Technology, P.O. Box 513, NL-5600 MB, Eindhoven (The Netherlands), Fax: (+31) 40-245-5054
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  • This research was performed within the framework of the CatchBio program. We gratefully acknowledge the support of the Smart Mix Program of the Netherlands Ministry of Economic Affairs and the Netherlands Ministry of Education, Culture and Science. E.J.M.H. and V.D. thank the Technology Foundation STW, the applied-science division of NWO. NWO-NCF and NWO-Dubble are acknowledged for access to computing and XAS facilities, respectively.

Abstract

original image

Koordination eines zweiten Katalysatormoleküls führt zu transienten Cr2+-Dimeren, die die Isomerisierung von Glucose zu Fructose vermitteln. Dieses Verhalten erklärt, warum CrCl2 die Dehydratisierung von Glucose zu 5-Hydroxymethylfurfural (HMF) in ionischen Flüssigkeiten so gut zu katalysieren vermag. Im geschwindigkeitsbestimmenden Schritt befindet sich das aktive Zentrum in einer ähnlichen Umgebung wie in Hexose-Isomerase-Enzymen.

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