Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation

Authors

  • Kai-Jiong Xiao,

    1. Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005 (China), Fax: (+86) 592-218-6400
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    • These authors contributed equally to this work.

  • Jie-Min Luo,

    1. Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005 (China), Fax: (+86) 592-218-6400
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    • These authors contributed equally to this work.

  • Ke-Yin Ye,

    1. Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005 (China), Fax: (+86) 592-218-6400
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  • Yu Wang,

    1. Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005 (China), Fax: (+86) 592-218-6400
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  • Pei-Qiang Huang Prof.

    1. Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005 (China), Fax: (+86) 592-218-6400
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  • We are grateful to the NSF of China (20832005) and the National Basic Research Program (973 Program) of China (grant no. 2010CB833200) for financial support.

Abstract

original image

Erst R1, dann R2: Ein effizienter und universeller Eintopfprozess für die reduktive doppelte Alkylierung von Lactamen oder Amiden mit Grignard- und Organolithiumreagentien wurde entwickelt (siehe Schema; DTBMP=2,6-Di-tert-butyl-4-methylpyridin, Tf=Trifluormethansulfonyl).

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