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Discrimination of Human Astrocytoma Subtypes by Lipid Analysis Using Desorption Electrospray Ionization Imaging Mass Spectrometry

Authors

  • Livia S. Eberlin,

    1. Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47907 (USA), Fax: (+1) 765-494-9421
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  • Allison L. Dill,

    1. Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47907 (USA), Fax: (+1) 765-494-9421
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  • Alexandra J. Golby Dr.,

    1. Department of Neurosurgery, Department of Radiology, and Department of Medical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 (USA), Fax: (+1) 617-264-6316
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  • Keith L. Ligon Dr.,

    1. Department of Neurosurgery, Department of Radiology, and Department of Medical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 (USA), Fax: (+1) 617-264-6316
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  • Justin M. Wiseman Dr.,

    1. Prosolia, Inc., Indianapolis, IN 46202 (USA)
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  • R. Graham Cooks Prof.,

    1. Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47907 (USA), Fax: (+1) 765-494-9421
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  • Nathalie Y. R. Agar Dr.

    1. Department of Neurosurgery, Department of Radiology, and Department of Medical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 (USA), Fax: (+1) 617-264-6316
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  • This work was supported by the U.S. National Institutes of Health (Grant 1R21EB009459-01) to L.S.E., A.L.D. and R.G.C., and by grants from the Brain Science Foundation, and the Daniel E. Ponton Fund for the Neurosciences to N.Y.R.A. Prosolia acknowledges support from the Indiana 21st Century Research and Technology Fund (J.M.W.). We gratefully acknowledge the assistance of Kristen K. Gill for tissue banking at BWH and Jessica Li of Prosolia for assistance in DESI-MS experiments.

Abstract

original image

Die Differenzierung von astrozytischen Hirntumorgraden kann durch direkte Lipidanalyse mittels Desorptions-Elektrosprayionisations-Massenspektrometrie (DESI-MS) erreicht werden. Charakteristische Lipidprofile sind mit der Tumormalignanz entsprechend den WHO-Graden II, III und IV assoziiert (siehe Bild).

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